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Sims can have both heterosexual and same-sex relationships and can be seen jumping under the sheets in bed to make "woohoo" (the game's term) -- which is accompanied by groans and giggles. The game encourages the pursuit of "nics stuff," because inferior quality products will negatively affect your Sim's mood such as sleeping in a cheap bed or cooking on a cheap stove.

We used Cox proportional hazard models to compute adjusted hazard ratios (a HRs) and 95 % confidence intervals (CIs) to estimate the relationship between QOL and survival.

Analyses of QOL items adjusted for age, sex, stage, body mass index, and physical activity showed that scores for poor physical functioning, dyspnea, anorexia, diarrhea, cough, personal strength, anxiety, and depression were associated with poor survival.

Characters can be dishonest, nasty, lustful, mean, and materialistic.

Characters can die and turn into ghosts, although it's also possible to control and even halt the aging process.

Not only are players afforded more options in body shape and clothing style and color than ever before, but they can also select five traits out of three dozen for their Sim, such as coward, absent-minded, athletic, and vegetarian, which affect everything from how the Sim behaves and interacts with other Sims to career choice and life aspirations.

The game's setting, the sprawling Sunset Valley, affords dozens of interesting locations to visit and hundreds of actions and reactions based on each Sim's personality.

As with previous Sims titles, The Sims 3 isn't suitable for younger players.

The game is a balanced and honest portrayal of peoples' foibles as well as their strengths.

We administered the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), the Quality of Life Questionnaire Lung Cancer Module (QLQ-LC13), Hospital Anxiety and Depression Scale (HADS), and Posttraumatic Growth Inventory (PTGI) to 809 survivors who were surgically-treated for lung cancer at two hospitals from 2001 through 2006.

We gathered mortality data by linkage to the National Statistical Office through December 2011.

THE SIMS 3, the latest game in EA's blockbuster Sims franchise, is a life simulation game where you create and control your own person, affectionately call a Sim.