Evidence: Evidence was obtained by extensive literature review and from clinical experience.
Consensus: Participants reviewed discussion summaries, voted, and reached a majority decision on each document section.
Two discussion documents were prepared by the organizing committee (without industry involvement) before the workshop, one on the evaluation and the other on the management of children with ISS.
These two review papers are published separately (4, 5), and the reader is invited to review them for further details.
ISS describes a heterogeneous group of children consisting of many presently unidentified causes of short stature.
It is estimated that approximately 60–80% of all short children at or below −2 SDS fit the definition of ISS (7).
Objective: Our objective was to summarize important advances in the management of children with idiopathic short stature (ISS).
Participants: Participants were 32 invited leaders in the field.
This definition of ISS includes short children labeled with constitutional delay of growth and puberty (CDGP) and familial short stature.
The frequency of referral of these children is dependent on the socioeconomic environment; furthermore, there is a greater perceived disability of short stature in boys compared with girls, irrespective of social class.
The predicted height may be inaccurate and is not an absolute criterion for GH treatment decisions.
The shorter the child, the more consideration should be given to GH.
Address all correspondence and requests for reprints to: Pinchas Cohen, M.